7/24/2015

When Does a Smart Mouse Become Human?



© DUSAN PETRICICLate last year, Steve Goldman of the University of Rochester and his colleagues reported that they had transplanted immature glial cells from donated human fetuses into the brains of immunodeficient mouse pups. These human glial cells matured into astrocytes and developed as the primary astrocyte population in the newborn mouse brain. One unexpected outcome of the team’s research, published in the Journal of Neuroscience (34:16153-61), was that these human-mouse chimeras outperformed normal mice almost fourfold in a variety of cognition tests, underscoring the importance of astrocytes in regulating synaptic plasticity and neural connectivity to enhance learning and memory. But the study also raised important ethical considerations—namely, what biological properties differentiate Homo sapiens from other organisms, and when should such “humanized” animals be afforded the rights that people currently enjoy.

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 http://www.the-scientist.com//?articles.view/articleNo/43327/title/When-Does-a-Smart-Mouse-Become-Human-/